Pathology Continued . . .
•Malignant potential?  Determined by . . .
–Cellular proliferation and tissue infiltration during acute foreign body reaction
–Fibrosis of the tissue capsule surrounding the FB
–Quiescence of the tissue reaction
–Direct contact with clonal preneoplastic cells
•No documented percentage for transformation.
Cancer Res. 1975 Feb ;35 (2):279-86 K G Brand , L C Buoen , K H Johnson , I Brand
Etiological factors, stages, and the role of the foreign body in foreign body tumorigenesis: a review.